Wouldn’t it be easier to just take a progesterone pill?

Dr. Lee recommends the transdermal cream rather than oral progesterone, because some 80% to 90% of the oral dose is lost through the liver.  Thus, at least 200-400 mg daily is needed orally to achieve a physiologic dose of 15 to 24 mg daily.  Such high doses create undesirable metabolites and unnecessarily overload the liver.

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